The H1N1 virus could make travel complicated during the holidays, especially if you get sick and have to cancel your travel plans. Each airline has different policies on refunds.  While most travelers  agree that you should stay home if you're sick, rescheduling a trip could cost $150 or more.  According to Newschannel 5, travel agents recommend buying insurance, and checking on the refund policy before you buy a plane ticket. 
The Atlanta Journal Constitution has a guide to traveling during flu season. Among the more useful tips - clean airplane tray tables with sanitizing wipes, and don't put anything in the seat pocket, where another passenger might have put dirty tissues.